The Bowery was the farmstead owned by Gotham founder Jon Logerquist. The property was eventually burned by the British when Logerquist refused to pay his taxes. Throughout Gotham's history, the Bowery has had an unsavory reputation; it has served as home to taverns and other hangouts for the criminal class. Crime Alley, the scene of the murder of Bruce Wayne's parents, Dr. and Mrs. Thomas Wayne, is located in the Bowery district.

Comprised of large single-family homes and mansions, on large tracts of land, Bristol is one of Gotham's most exclusive neighborhoods. Set on the bay, it is also home to numerous yacht basins and the Gotham Tennis Hall of Fame. Wayne Manor is in this area.

Bryanttown is a slum area and the site of several low-income housing projects that have suffered long under civil neglect. The neighborhood is plagued by drugs, street crime, and numerous youth gangs who are engaged in constant warfare for control of the projects and the streets.

The Central Business District is an area of old neoclassical architecture overpowering and shadowing the streets below. Banks, stock exchanges, and other financial institutions dominate the area. The CBD is home to the Gotham Stock Exchange as well as the Butler Museum of Modern Art, the Gotham Art Institute, the Gotham Museum of Natural History, the Gotham Theater District, and the Gotham State Building, the tallest structure in the city (1350 feet).

Charon is a residential neighborhood of broad boulevards and narrow, winding streets lined with every conceivable type of housing. This area is home to Gotham Mercy Hospital, and several of the cities largest cemeteries.

Chinatown is home to a solid and traditional Chinese community. Known for its restaurants and Oriental markets, Chinatown is considers itself a self-contained community that neither asks for nor, it feels, requires assistance from outsiders.

Coventry is a middle-class area of neat , brick houses whose residents are attempting to keep crime and corruption of neighboring Manchester from infecting their community. Coventry's three most famous institutions are Gotham Zoo (the oldest zoo in the nation), the Hegler Historical Historical Library, and the Priory (the largest monastery in North America).

The East River is a low-rent district that was once a fashionable neighborhood for the city's gangsters and nouveau rich of the Prohibition era. The neighborhood is presently plagued with gang activity.

Evanston is a small, quiet community of mostly single-family homes on one-half acre plots. A local ordinance prohibits any structure taller than four stories.

Glendale was annexed by Gotham City in the 1930s. This middle-class area still maintains the flavor of a city-within-a-city, complete with its own miniature version of the Central Business District. The Gotham Institute of Technology makes its home within this section of the city.

Situated on the edge of the Dayton Forest Preserve, Irving Grove is an upper-middle-class of condos and small housing developments. The surrounding Dayton Forest Preserve is a national park established by wealthy manufacturer Nathaniel Dayton.

Little Stockton was once bustling with heavy industry. However, the deterioration of Lyntown, brought on by the decline in working factories in that area, was averted in Little Stockton by the creation of a number of middle-technology outfits. High-grade steel, Special plastics, and ceramics are a specialty of the area. Gotham International airport is located here.

The Upper East side dates back to the 1800s, when it became home to factory workers who resided in the tenement apartment buildings. Most of the residents of this area are employed in the nearby rail yards and factories.

Lyntown used to be the industrial heart of Gotham. It now consists of mainly abandoned factories, some of which have been empty for as long as fifteen years. Only a few legitimate concerns are still operating in Lyntown, with the majority of commerce being found in the drug refineries, stolen car (chop) shops, and machine shops (for weapons manufacture), that have taken over the factories.

Manchester is residential area with a rich ethnic mix. This area is comprised of a number of smaller sub-neighborhoods, each zealously guarded by its own street gangs. The citizens of Gotham brave the gang violence to take advantage of the ethnic restaurants that serve the neighborhood, as well as to attend the races at the Manchester Viaduct.

Midtown is an ethnic neighborhood with a heavy concentration of families descended from earlier Eastern European immigrants. Recent years have seen a growth of East Indian immigrants settling in the area as well. The Gotham branch of S.T.A.R. Labs is located here.

Once a seedy dock district, much of Neville has been razed to make way for all types of middle class housing, from single-family homes to multi-unit dwellings. Neville is known for its night spots and trendy restaurants and has until recently attracted the attention of young professionals.

Scituate is an area of tidy suburban housing originally built for the workers employed in the factories of Lyntown. Gotham's sport stadiums, which include Gotham Stadium, Wayne Field, and Dean Stadium, are located here.

Home to the annual Swedish Celebration, Sommerset is a neighborhood rich in cultural heritage. This community is a Nordic enclave which dates back to the days of Gotham's settling. Sommerset is also the scene of the annual Sommerset Shakespeare Festival, which is held in an outdoor amphitheater that is believed to have been used by the Indians centuries before Europeans settled in the area. Arkham Asylum is located within the outskirts of Sommerset.

The population of Uptown is a mix of varying social and economic groups. Factory workers and young professionals live side-by-side, not far from the small shops and exclusive boutiques in its shopping areas.

Victoria Place is an area of small and mid-sized companies, most of which are engaged in the research and manufacture of technology.

The Waterfront is one of Gotham's most vastly improved areas. Recent years have seen the improvement and enlargement of the peers to accommodate newer cargo container ships, the widening of surrounding streets to handle the flow of truck traffic to and from the docks. Efforts have been made to clean the criminal element out of the Waterfront in light of its resurgent property.